Myo-inositol in the treatment of premenstrual dysphoric disorder
Objective Premenstrual dysphoric disorder (PMDD) is a mood disorder disrupting social and/or occupational life of affected women. Premenstrual dysphoric disorder etiology is unknown, although a pivotal role is played by the serotoninergic system. Indeed, one of the most effective treatments is selective serotonin reuptake inhibitors. Several studies have proposed a selective serotonin reuptake inhibitor-like role […]
Integratore alimentare in gravidanza e allattamento
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Inositol safety clinical evidences
Myo-inositol is a six carbon cyclitol that contains five equatorial and one axial hydroxyl groups. Myo-inositol has been classified as an insulin sensitizing agent and it is commonly used in the treatment of the Polycystic Ovary Syndrome (PCOS). However, despite its wide clinical use, there is still scarce information on the myo-inositol safety and/or side […]
The D-chiro-inositol paradox in the ovary
The D-chiro-inositol–to–myo-inositol ratio is regulated by an insulin-dependent epimerase. Enzyme activity varies among tissues, likely owing to the specific needs of the two different molecules. We hypothesize that in the ovaries of polycystic ovary syndrome patients, epimerase activity is enhanced, leading to a local myo-inositol deficiency which in turn is responsible for the poor oocyte […]
Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality
Objective: Polycystic ovary syndrome (PCOS) is the most common cause of infertility due to menstrual dysfunction, and the most promising treatments for this disease are insulin sensitising agents. Myo-inositol and D-chiro-inositol are insulin sensitizing agents used in PCOS treatment. In the present paper, we aimed to compare the effects myo-inositol and D-chiro-inositol on oocyte quality […]
The effect of a combination therapy with myo-inositol and a combined oral contraceptive pill versus a combined oral contraceptive pill alone on metabolic, endocrine, and clinical parameters in polycystic ovary syndrome
Aim. Compare the effects of a combined contraceptive pill (OCP) in combination with myo-inositol (MI) on endocrine, metabolic, and clinical parameters in patients with polycystic ovary syndrome (PCOS). Methods. One hundred fifty-five patients with PCOS were enrolled in this prospective, open-label clinical study. Patients were assigned to receive oral treatment with OCP alone (estradiol (EE) […]
Inositol activity in oligoasthenoteratospermia – An in vitro study
Background: Oligoasthenoteratospermia, a reduction in motilty and number of spermatozoa and a change in their morphology, is one of the most relevant causes of infertility in men. One of the factors, which may influence male infertility is linked to the production of reactive oxygen species (ROS) by morphologically altered spermatozoa. Spermatozoa are more susceptible than […]
Inositol activity in oligoasthenoteratospermia An in vitro study
Background: Oligoasthenoteratospermia, a reduction in motilty and number of spermatozoa and a change in their morphology, is one of the most relevant causes of infertility in men. One of the factors, which may influence male infertility is linked to the production of reactive oxygen species (ROS) by morphologically altered spermatozoa. Spermatozoa are more susceptible than […]
Melatonina e sistema riproduttivo maschile
La più semplice spiegazione del perché la melatonina abbia un effetto sul sistema riproduttivo, viene, ancora una volta, dall’ attenta osservazione della natura. Infatti, in natura, un numero considerevole di specie animali, escluso l’uomo, è sottoposto ad un ritmo riproduttivo che consente la nascita dei piccoli durante il periodo più favorevole. II fenomeno è particolarmente importante […]
The sutures in dentistry
In oral surgery, the last phase of a surgical operation is represented by the tissues suture, that allows the wound lips edges approximation and their stabilization, to promote haemostasis, to avoid the alimentary residues accumulation on the incision line and allow the first intention healing. A good suture avoids that the displacing forces generated by […]