Peripheral neuropathy in obstetrics: efficacy and safety of α-lipoic acid supplementation
OBJECTIVE: Neuropathic pain during pregnancy is a common condition due to the physical changes and compression around pregnancy and childbirth that make pregnant women more prone to develop several medical conditions such as carpal tunnel syndrome, sciatica, meralgia paraesthetica and other nerve entrapment syndromes. Most of the treatments usually performed to counteract neuropathic pain are […]
Inositoli: storia e personaggi di una terapia efficace
La storia dell’inositolo è una storia complessa: nel 1850 Johanes Joseph Scherer isolò dal muscolo un esaidrocicloesano a cui diede il nome di inositolo 1 (dal greco inos= muscolo). La struttura del cicloesano permette la formazione di nove diversi stereoisomeri. Tra essi, ii myo-inositolo è l’isomero di gran lunga più distribuito in natura (Fig. 1.1). […]
Updates on the myo-inositol plus D-chiro-inositol combined therapy in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age. It is characterized by chronic anovulation, hyperandrogenism, and insulin resistance. It is the main cause of infertility due to the menstrual dysfunction and metabolic disorders. Women with PCOS also have an increased cardiovascular risk because of dyslipidemia and […]
Uno zucchero per l’ovaio policistico – Sulle Ali della Salute
Myo-inositol ovarian stimulation and IVF outcomes
OBJECTIVE: More than 60% of in vitro fertilization (IVF) cycles do not result in pregnancy. Several studies have been carried out in order to identify factors affecting the IVF outcome. The main factors influencing IVF outcome are oocyte and embryo quality. Indeed, the only way to improve IVF success rate is toimprove oocyte and embryo […]
Hereditay hemorragic teleangectasia and pregnancy
We report an uncommon case of a 38-years-old pregnant woman affected by HHT (Hereditary haemorrhagic telangiectasia; OslerWeber-Rendu syndrome) who underwent to a caesarean section (CS) without any complication. The patient at 36th weeks+1 day pregnancy referred to the Emergency Obstetric Unit due to a intercostals pain on left side. On third day after admission the […]
Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects
Objective: Neural tube defects (NTDs) are classified as folate sensitive (about 70%) and folate resistant (about 30%); although folic acid is able to prevent the former, several data have shown that inositol may prevent the latter. It has recently been proposed that coffee intake might represent a risk factor for NTD, likely by interfering with […]
Efficacy and safety of 17a-hydroxyprogesterone caproate in hormone replacement therapy
The aim of the present study was to evaluate the efficacy (in terms of induction of uterine bleeding) and safety (in terms of absence of endometrial hyperplasia) of 17a-hydroxyprogesterone caproate (17a-HPC) in a therapeutic regimen for hormonal replacement after menopause. Fifty postmenopausal patients received hormone replacement therapy (HRT) for 24 weeks. The treatment regimen consisted […]
Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use
Objective: Dose-dependent side effects related to myo-inositol (MI) oral administration represent a significant shortcoming for its clinical use. Aiming to search for a pharmaceutical form able to be better absorbed, the pharmacokinetic (PK) profile of the new manufactured MI soft gelatin capsule form was evaluated and compared with the commercially available MI powder. Research design and methods: A single-dose […]
Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use
Objective: Dose-dependent side effects related to myo-inositol (MI) oral administration represent a significant shortcoming for its clinical use. Aiming to search for a pharmaceutical form able to be better absorbed, the pharmacokinetic (PK) profile of the new manufactured MI soft gelatin capsule form was evaluated and compared with the commercially available MI powder. Research […]