Results from the International Consensus Conference on Myo-inositol and D-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS
Metabolic syndrome (MS) is a combination of disorders characterized by alterations in carbohydrate metabolism, obesity, systemic arterial hypertension and dyslipidemia, which increase the risk of developing cardiovascular disease and diabetes. Metabolic disorders affect reproductive function controlled by the hypothalamus and the pituitary. A clinical example of such an interaction is represented by Polycystic ovary syndrome […]
Second trimester amniotic fluid myo-inositol concentrations in women
Second trimester amniotic fluid myo-inositol concentrations in women later developing gestational diabetes mellitus or pregnancy-induced hypertension: Objective: To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension. Methods: A retrospective study was carried out with three groups of amniotic fluid samples (15–18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational […]
Inositol safety clinical evidences
Myo-inositol is a six carbon cyclitol that contains five equatorial and one axial hydroxyl groups. Myo-inositol has been classified as an insulin sensitizing agent and it is commonly used in the treatment of the Polycystic Ovary Syndrome (PCOS). However, despite its wide clinical use, there is still scarce information on the myo-inositol safety and/or side […]
Reflections on inositol(s) for PCOS therapy (Nestler-Unfer 2015)
In polycystic ovary syndrome (PCOS) pathogenesis, both the insulin resistance and the related compensatory hyperinsulinemia are involved. Despite their similarities, Myo-inositol (MI) and D-chiro-inositol (DCI) play different roles in PCOS etiology and therapy. Indeed, in tissue such as the liver both molecules are involved in the insulin signaling, i.e. MI promotes glucose uptake and DCI […]
Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – assisted reproduction technology
A substantial body of research on mammalian gametogenesis and human reproduction has recently investigated the effect of myo-inositol (MyoIns) on oocyte and sperm cell quality, due to its possible application to medically assisted reproduction. With a growing number of both clinical and basic research papers, the meaning of several observations now needs to be interpreted […]
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Updates on the myo-inositol plus D-chiro-inositol combined therapy in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age. Scarica il documento (PDF)
Infertilità – Sulle Ali della Salute
Myo-inositol in Down syndrome amniotic fluid. A case-control study.
Myo-inositol is involved in metabolic changes that characterize Down syndrome This study shows that Down syndrome metabolic changes occur very early in the fetal life, with amniotic fluid myo-inositol concentrations increasing since the mid-trimester. A possible clinical use of this finding maybe interesting Scarica il documento (PDF)
Polycystic Ovary Syndrome: Features, Diagnostic Criteria and Treatments
Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorder that affects 6–15% of the female population. It is a very complex syndrome that involves the hypothalamus, the pituitary gland, the ovaries, the adrenal gland and the peripheral adipose tissue that together contribute to create a generally imbalance, associated with three […]